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Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy

NCT06145191 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1013

Last updated 2025-08-01

No results posted yet for this study

Summary

Endobronchial bleeding is a common complication of bronchoscopy. Major bleeding, although rare, can be life threatening and often requires advanced therapeutic interventional pulmonary procedures which are not widely available. Minor bleeding can negatively impact outcomes such as diagnostic yield, sample size and bronchoscopy duration. Both adrenaline and tranexamic acid are successfully used topically for hemostasis during diagnostic bronchoscopy. The aim of this study is to evaluate the efficacy of prophylactically applied adrenaline and tranexamic acid in bleeding prevention during diagnostic bronchoscopy.

Conditions

Interventions

DRUG

Tranexamic acid

Prophylactic topical application (1x) of tranexamic acid (100mg, 2ml, room temperature) before sampling

DRUG

Adrenaline

Prophylactic topical application (1x) of adrenaline (1:10.000, 2ml, room temperature) before sampling

DRUG

Placebo

Prophylactic topical application (1x) of placebo (0.9% NaCl, 2ml, room temperature) applied before sampling

Sponsors & Collaborators

  • Clinical Hospital Centre Zagreb

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-18
Primary Completion
2025-03-28
Completion
2025-03-28

Countries

  • Croatia

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06145191 on ClinicalTrials.gov