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The Effect of Green Coffee Extract on Blood Glucose Homeostasis in Healthy Adults

NCT06137066 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2024-05-10

No results posted yet for this study

Summary

Green coffee extract (GCE) supplementation has been shown to induce favourable health benefits on glucose metabolism and weight management. Previous literature suggests that the benefits of GCE are due to the high bioavailability of chlorogenic acid (CGA) which is known for its antioxidant and anti-inflammatory properties but is destroyed during the bean roasting process used to make coffee in Western societies. While some studies examining chronic and high-dose GCE supplementation (4-12 weeks) report beneficial effects on glucose handling and reductions in body mass following supplementation, comparably less is known about the effect of acute (single dose) GCE supplementation. The purpose of the current study is to determine the impact of acute supplementation of GCE on blood sugar levels following consumption of a carbohydrate drink in healthy adults. A secondary objective is to evaluate the effect of GCE on insulin levels, other measures of glucose metabolism, and appetite perceptions.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

200mg GCE +200mg ALA

200mg green coffee extract + 200mg alpha-lipoic acid

DIETARY_SUPPLEMENT

200mg GCE +400mg ALA

200mg green coffee extract + 400mg alpha-lipoic acid

DIETARY_SUPPLEMENT

200mg GCE + 200mg DHB

200mg green coffee extract + 200mg dihydroberberine

DIETARY_SUPPLEMENT

Placebo

microcrystalline cellulose with 5 mg magnesium stearate and 5 mg silicon dioxide

Sponsors & Collaborators

  • Iovate Health Sciences International Inc

    collaborator INDUSTRY

  • Dr. Chris McGlory, PhD

    lead OTHER

Principal Investigators

  • Chris McGlory · Queen's University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-12-01
Primary Completion
2024-05-08
Completion
2024-05-08

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06137066 on ClinicalTrials.gov