MedTrace Logo

BHB and Cognition During Exercise-Heat Stress

NCT07010666 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2025-06-08

No results posted yet for this study

Summary

The study investigates how consuming a ketone ester (BHB) along with caffeine impacts cognitive performance under heat stress, similar to what military personnel experience in hot environments. The extreme heat can impair brain function, affecting decision-making and performance, which is critical for Special Operations Forces (SOF). BHB provides an alternative energy source for the brain, potentially improving brain blood flow and cognition, particularly during "stressful" situations. By comparing ketone and carbohydrate intake with caffeine, this study aims to find better ways to maintain mental sharpness during stressful conditions. The results could help enhance the safety and effectiveness of military operations.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Beta-Hydroxybutyrate

25 grams of BHB

DIETARY_SUPPLEMENT

Carbohydrate

25 grams of carbohydrate

DIETARY_SUPPLEMENT

Caffeine

4 mg/kg of caffeine

Sponsors & Collaborators

  • University of South Carolina

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-29
Primary Completion
2025-05-12
Completion
2025-05-12

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07010666 on ClinicalTrials.gov