Pseudoexfoliation Syndrome, Sarcopenia and Chronic Pain

Summary

Aim: Pseudoexfoliation syndrome (PEX) is a systemic disease of connective tissue, it can also contribute to sarcopenia and chronic musculoskeletal pain with common pathways.

1. First aim of this study was to investigate whether the rate of sarcopenia is higher in patients with PEX
2. Second aim was to investigate the association between PEX, sarcopenia parameters and chronic musculoskeletal pain.

Methods: A total of 96-patients were enrolled in this study and divided into two groups: PEX-positive (n=48) and PEX-negative (n=48) patients. The variables: the demographic data, sarcopenia parameters (SARC-F-questionnaire, hand-grip strength, chair-rise test, gait speed) and pain parameters (having any chronic musculoskeletal pain, pain regions and visual analogue scale-pain).

Conditions

• Sarcopenia
• Pseudoexfoliation Syndrome

Interventions

DIAGNOSTIC_TEST

SARC-F questionnaire

The SARC-F scale has 5 questions which evaluate strength, assistance in ambulation, rising from a chair, stair climbing, and falls. The cut off point for predicting sarcopenia is score 4; "4 and more" means risk of sarcopenia.

DIAGNOSTIC_TEST

Gait speed

Low gait speed was defined as walking below than 0.8 meters per second.

DIAGNOSTIC_TEST

The chair rise test

the chair rise test (measures the strength of leg muscles), it measures the time taken for 5 times of rising from the sitting position without using arms, and was defined as low when the time taken was more than 15 seconds

DIAGNOSTIC_TEST

Grip strength

Grip strength was measured with a hand-held dynamometer (Baseline, White Plains, New York, USA), and the cut-off thresholds were 32 kg for males and 22 kg for females

DIAGNOSTIC_TEST

Visual analog scale

The visual analogue scale (VAS) was used for measuring general body pain severity, which was assessed from 0 (no pain) to 10 (worst possible pain)

Sponsors & Collaborators

• Eskisehir Osmangazi University

  lead OTHER

Principal Investigators

• Fulya Bakılan, Assoc Prof · Eskişehir Osmangazi University

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-03-30

Primary Completion

2023-08-15

Completion

2023-10-25

Countries

• Turkey (Türkiye)

Study Locations