Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia

Summary

The study tests the effect of the ATNC MDD-V1 on Alzheimer patients' cognitive function. The ATNC MDD-V1 uses non-invasive stimulation of both magnetic and cognitive training.

Conditions

• Alzheimer's Disease
• Dementia
• Brain Diseases
• Central Nervous System Diseases
• Nervous System Diseases
• Neurodegenerative Diseases
• Neurocognitive Disorders
• Mental Disorder

Interventions

DEVICE

ATNC MDD-V1 (Real TMS + Real Cog)

Synchronized TMS and cognitive stimulation to 6 brain areas.

DEVICE

ATNC MDD-V1 (Sham TMS + Real Cog)

Sham device, has the same appearance and sound as the real device, combined with real cognitive exercises. Patients come for the same number of sessions, delivers no real stimulation or cognitive training.

DEVICE

ATNC BN-V1

The navigation system is used to determine the exact brain location to be stimulated (coordinates for the stimulation point).

DEVICE

ATNC BN-V2

The navigation system is used to determine the exact brain location to be stimulated (coordinates for the stimulation point).

Sponsors & Collaborators

• Chungnam National University Hospital

  collaborator OTHER

• Korea University Anam Hospital

  collaborator OTHER

• Dong-A University Hospital

  collaborator OTHER

• Chonnam National University Hospital

  collaborator OTHER

• Chonbuk National University Hospital

  collaborator OTHER

• Chung-Ang University Gwangmyeong Hospital

  collaborator OTHER

• Yeungnam University Hospital

  collaborator OTHER

• Inje University Ilsan Paik Hospital

  collaborator OTHER

• National Health Insurance Service Ilsan Hospital

  collaborator OTHER

• Konkuk University Medical Center

  collaborator OTHER

• Advanced Technology & Communications

  lead INDUSTRY

Principal Investigators

• Ae Young MD LEE, PhD · Chungnam National University Hospital

• Kun Woo MD Park, PhD · Korea University Anam Hospital

• Deye MD Yoon, PhD · Dong-A University Hospital

• Goun MD Kim, PhD · Chonbuk National University Hospital

• Su-Hyun MD Jo, PhD · Chonnam National University Hospital

• Mincheol MD Park, PhD · Chung-Ang University Gwangmyeong Hospital

• Inwook MD Song, PhD · Incheon St.Mary's Hospital

• Miyoung MD Park, PhD · Yeungnam University Hospital

• Younggeon MD Lee, PhD · Inje University Ilsan Paik Hospital

• Sohun MD Yoon, PhD · National Health Insurance Service Ilsan Hospital

• Yeonsil MD Moon, PhD · Konkuk University Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-05-15

Primary Completion

2027-01-15

Completion

2027-06-30

Countries

• South Korea

Study Locations