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Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome

NCT06051110 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5239

Last updated 2026-03-18

No results posted yet for this study

Summary

Patients with a non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are currently transported and admitted to the nearest emergency department (ED) for risk stratification, diagnostic workup, and treatment. Recently, several prospective studies have been performed on the diagnostic performance of point-of-care (POC)-troponin and combined risk scores (CRS) for pre-hospital risk assessment and triage of NSTE-ACS patients. Also the first intervention trials on triage decisions based on POC troponin and CRS have been performed. Initial results are indicating that prehospital triage based on these diagnostic tools is feasible and safe, although sample sizes were relatively small and underpowered to detect differences in major adverse cardiac events (MACE). The objective of this individual patient data meta-analysis is to determine the diagnostic performance of POC troponin and combined risk scores for prehospital risk assessment and triage in suspected NSTE-ACS patients.

Conditions

  • Acute Coronary Syndrome
  • Non ST Segment Elevation Acute Coronary Syndrome

Interventions

DEVICE

Combined risk score

Prehospital risk stratification by the use of a combined clinical risk score including POC-troponin

OTHER

Usual care

Prehospital risk stratification by EMS protocols

DEVICE

point-of-care troponin

Prehospital risk stratification by the use of a POC-troponin

Sponsors & Collaborators

  • Catharina Ziekenhuis Eindhoven

    lead OTHER

Principal Investigators

  • Pieter-Jan Vlaar, MD, PhD · Catharina Ziekenhuis Eindhoven

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2024-12-01
Completion
2026-01-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06051110 on ClinicalTrials.gov