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Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma

NCT06044051 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-02-17

No results posted yet for this study

Summary

Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment.

Exploring and understanding these data is to improve patient care and discover new therapeutic targets.

The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.

Conditions

Interventions

OTHER

Blood sample

An additionnal volume of blood will be collected at inclusion and at each follow-up visit

OTHER

Expectoration

Expectoration will be collected at inclusion and at each follow-up visit

OTHER

Nasopharyngeal swab

A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum

Sponsors & Collaborators

  • University Hospital, Rouen

    lead OTHER

Principal Investigators

  • PETAT Hortense · University Hospital, Rouen

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Max Age
24 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-26
Primary Completion
2026-09-26
Completion
2026-09-26

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06044051 on ClinicalTrials.gov