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Antibiotic Treatment of Recurrent Episodes of Asthma in Children

NCT01233297 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-03-18

No results posted yet for this study

Summary

Copsac has discovered that asthmatic exacerbations are as closely linked to bacterial as to viral infection. The current study will examine whether treatment of asthmatic exacerbations with macrolide antibiotics - in the abscence of clear clinical bacterial infection which would in any case precipitate antibiotic treatment - has an effect on either the particular episode, or subsequently. Macrolide antibiotics are chosen for ease of administration ensuring high compliance, antibiotic appropriacy, and anti-inflammatory properties.

Conditions

  • Childhood Asthma With Acute Exacerbation

Interventions

DRUG

Azithromycin

10 mg/kg peroral for 3 consecutive days

OTHER

Placebo mixture

Placebo mixture containing no active substance.

Sponsors & Collaborators

  • Copenhagen Studies on Asthma in Childhood

    lead OTHER

Principal Investigators

  • Klaus Bønnelykke, MD, PhD · Copenhagen Studies on Asthma in Childhood

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
1 Year
Max Age
3 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-11-30
Primary Completion
2027-10-31
Completion
2033-10-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01233297 on ClinicalTrials.gov