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Type 2 Innate Lymphoid Cells in Severe Pediatric Asthma

NCT03784781 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2025-09-25

No results posted yet for this study

Summary

The main objectives of this study are to show that the number of type 2 innate lymphoid cells (ILC2) of the bronchial mucosa and in bronchoalveolar lavages (BAL) are higher in asthmatic children than in non-asthmatics, that the number of ILC2 of the bronchial mucosa and in BAL correlate with the number of bronchial and BAL eosinophils, and to determine whether there is a correlation between plasma and bronchial and BAL ILC2.

Conditions

Interventions

BIOLOGICAL

Biopsy

Mucosal biopsies under general anesthesia of the segmental bronchi of the right or left lower lobe

BIOLOGICAL

Blood collection

Blood collection (+15mL/ current care)

BIOLOGICAL

Bronchoalveolar lavage

Bronchoalveolar lavage fluid (3mL/Kg)

Sponsors & Collaborators

  • URC-CIC Paris Descartes Necker Cochin

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Guillaume Lezmi, MD, PhD · Assistance Publique - Hôpitaux de Paris

Eligibility

Min Age
6 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-06-09
Primary Completion
2020-04-30
Completion
2020-04-30

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03784781 on ClinicalTrials.gov