Angiography-Derived Quantitative Functional Assessment Versus Pressure-Derived FFR and IMR: The FAIR Study

Summary

Coronary angiography-derived FFR assessment (AngioQFA) is a novel technique for physiological lesion assessment based on 3-dimensional (3D) quantitative coronary angiography (QCA) and virtual hyperemic flow derived from contrast frame count without drug-induced hyperemia. The goal of this prospective, multicenter trial is to compare the diagnostic performance of AngioQFA with invasive FFR as the reference standard. The secondary purpose is to compare the diagnostic accuracies of the computational fluid dynamics (CFD)-based index of microcirculatory resistance (IMR) using wire-based IMR as the reference standard.

Conditions

• Coronary Artery Disease
• Heart Diseases
• Cardiovascular Diseases
• Arteriosclerosis
• Coronary Stenosis
• Vascular Diseases
• Ischemia

Interventions

OTHER

AngioQFA

FFR measured by pressure wire, AngioQFA computed by coronary angiographic images

Sponsors & Collaborators

• Renmin Hospital of Wuhan University

  collaborator OTHER

• Yan'an Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• Sir Run Run Shaw Hospital

  collaborator OTHER

• Jieyang People's Hospital

  collaborator OTHER

• Eighth Affiliated Hospital, Sun Yat-sen University

  collaborator OTHER

• Shenzhen Raysight Intelligent Medical Technology Co., Ltd.

  lead INDUSTRY

Principal Investigators

• Hong Jiang · Renmin Hospital of Wuhan University

• Qiang Xue · Yan'an Affiliated Hospital of Kunming Medical University

• Guosheng Fu · Sir Run Run Shaw Hospital

• Jianwen Liang · The Eighth Affiliated Hospital of Sun Yat-sen University

• Qiang Wu · Jieyang People's Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-09-13

Primary Completion

2024-01-14

Completion

2024-01-14

Countries

• China

Study Locations