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Intestinal Flora and Metabonomics of Appendicitis

NCT06035029 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2023-09-13

No results posted yet for this study

Summary

The goal of this observational study is to learn about the key bacterial flora and metabolites associated with appendicitis in children. The main questions it aims to answer are:

* To screen out the key biomarkers of pediatric appendicitis.
* What are the microbial differences in different parts of pediatric appendicitis patients.

Participants will detect feces using 16s ribosomal RiboNucleicAcid (16S rRNA) gene sequencing technology and differences of the fecal metabolites between healthy children and appendicitis children were analyzed using untargeted metabolomics based on Liquid chromatography-tandem mass spectrometry(LC-M S/MS) platform.Through the analysis of intestinal bacterial flora and metabolomics association and the differential analysis of intestinal bacterial flora in different parts of the case group, the key bacterial flora and metabolites were excavated.

Conditions

  • Appendicitis
  • Intestinal Metaplasia
  • Metabonomics

Sponsors & Collaborators

  • HongyiQu

    lead OTHER

Principal Investigators

  • Qu · Shandong First Medical University

Eligibility

Min Age
1 Year
Max Age
14 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-04-03
Primary Completion
2025-01-31
Completion
2025-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06035029 on ClinicalTrials.gov