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Development and Validation of a Nomogram Predicting the Probability of in Hirschsprung Children Following Surgery

NCT06025188 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2023-09-06

No results posted yet for this study

Summary

Postoperative soiling is a common complication following Hirschsprung disease \[HSCR\] surgery. The aim of this study was to develop a nomogram for predicting the probability of postoperative soiling in patients aged \>1 year operated for HSCR. The investigators retrospectively analyzed HSCR patients with surgical therapy over one year of age from January 2000 and December 2019 at our department. Eligible patients were randomly categorized into the training and validation set at a ratio of 7:3. By integrating the least absolute shrinkage and selection operator \[LASSO\] and multivariable logistic regression analysis, crucial variables were determined for establishment of nomogram. And, the performance of nomogram was evaluated by C-index，area under the receiver operating characteristic curve \[ROC\], calibration curves, and decision curve analysis \[DCA\]. Meanwhile, a validation set was used to further assess the model.

Conditions

  • Develop a Nomogram

Interventions

OTHER

training set

LASSO regression analysis, Logistic regression analysis, Nomogram

Sponsors & Collaborators

  • Tongji Hospital

    lead OTHER

Eligibility

Min Age
1 Year
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-01
Primary Completion
2021-08-01
Completion
2022-08-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06025188 on ClinicalTrials.gov