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Melatonin for Knee Osteoarthritis Patients

NCT06012175 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 340

Last updated 2025-11-20

No results posted yet for this study

Summary

By recruiting knee osteoarthritis patients and treating them with melatonin, this study aims to determine the efficacy and safety of melatonin in alleviating pain in this patient population.

Conditions

  • Osteoarthritis, Knee

Interventions

DIETARY_SUPPLEMENT

Melatonin

One 3 mg melatonin tablet every night before bedtime for 12 weeks

DIETARY_SUPPLEMENT

Placebo

One placebo tablet, having an identical appearance to the melatonin tablet, every night before bedtime for 12 weeks

Sponsors & Collaborators

  • Peking University People's Hospital

    collaborator OTHER

  • West China Hospital

    collaborator OTHER

  • Massachusetts General Hospital

    collaborator OTHER

  • School of Medicine, University of Nottingham

    collaborator UNKNOWN

  • Xiangya Hospital of Central South University

    lead OTHER

Principal Investigators

  • Chao Zeng, MD, PhD · Xiangya Hospital of Central South University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-02
Primary Completion
2025-09-24
Completion
2025-09-24

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06012175 on ClinicalTrials.gov