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Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids

NCT06008184 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2023-09-06

No results posted yet for this study

Summary

Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have limitations.

Therefore, a non-invasive and ambulatory method would be useful to measure cortisol levels in real-time.

The main aim of the study is to compare cortisol levels across biological fluids (sweat, saliva, interstitial fluid, and blood) in order to validate in the long term a continuous and non-invasive cortisol measurement device (currently under development).

Conditions

Interventions

OTHER

24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva)

24 hours sampling of 4 biological fluids: * blood: sampling every 20 minutes (through a venous catheter) * ISF: automated sampling every 20 minutes (microdialysis technique connected to U-Rhythm device) * Sweat : collection of 1 to 3 samples at 4 differents timepoints * Saliva : sampling every hour (except during the night)

OTHER

24 hours sampling of ISF or sweat (after validating the correlation with blood)

24 hours sampling in an ambulatory setting

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Nelly Pitteloud, MD · Centre Hospitalier Universitaire Vaudois

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-01
Primary Completion
2024-08-31
Completion
2024-08-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06008184 on ClinicalTrials.gov