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Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms

NCT03974789 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 380

Last updated 2025-11-17

No results posted yet for this study

Summary

Automated immunodosage methods (Roche Elecsys cortisol and IDS cortisol dosing kits) offer a simple and inexpensive technology routinely used in a medical biology laboratory. They can be used to define robust diagnostic thresholds for salivary cortisol for the diagnosis of Cushing's syndrome and pseudo-Cushing combining the three tests performed as part of the patient's usual management. (ie two urinary free cortisol (UFC), the dexamethasone suppression test, and Diurnal variation of plasma cortisol).

Conditions

  • Cushing Disease

Interventions

DIAGNOSTIC_TEST

Blood test

Plasma cortisol level test

DIAGNOSTIC_TEST

24-hour Urine test

Urinary free cortisol test

DIAGNOSTIC_TEST

Saliva swab

salivette® for salivary cortisol quantification

DIAGNOSTIC_TEST

Dexamethasone test

Dectancyl® 2 x 0.5 mg tablets (total 1 mg)

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Nīmes

    lead OTHER

Principal Investigators

  • David de Brauwere · CHU Nimes

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2025-07-01
Completion
2026-07-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03974789 on ClinicalTrials.gov