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The Impact of Coagulation Disorders on the Diagnosis and Prognosis of Sepsis

NCT05998733 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 552

Last updated 2023-08-21

No results posted yet for this study

Summary

The study was a retrospective, single-center clinical study. From all patients admitted to the emergency ICU during the period of 2013.1.1-2019.12.31, the investigators screened all patients who met the criteria of 1) ≤7 days from symptom onset to enrollment; 2) patients who also met the criteria of the presence of clinical infections and Sequential Organ Failure Assessment (SOFA) score ≥2; and 3) met the exclusion criteria, and retrospectively collected coagulation indices of the patients before anticoagulation with or without the use of heparin or low molecular heparin, and recorded the worst values of coagulation function of patients before heparin were recorded, and the organ function, inflammatory response, immune indexes, and conversion rate of severe disease were observed, so as to investigate the role of conventional coagulation indexes (FDP, D-dimer) and thromboelastography in the early diagnosis of septicemia patients and to indicate the prognosis.

Conditions

Interventions

DIAGNOSTIC_TEST

Early general coagulation function (5 items of coagulation) and thromboelastogram monitoring

* Correlation analysis of sepsis severity with FDP and D-Dimer * Discussion on the critical value and area under the curve of FDP and D-Dimer in diagnosis of sepsis * Differences in age and sex of FDP and D-Dimer in diagnosis of sepsis * Effect of FDP and D-Dimer diagnosis of sepsis on severe conversion rate and all-cause mortality of patients * The difference of thromboelastogram in patients with sepsis of different severity * Thromboelastogram items (R time α Correlation between angle, k time, maximum blood clot strength and comprehensive coagulation index) and sepsis

Sponsors & Collaborators

  • Ruijin Hospital

    lead OTHER

Principal Investigators

  • Enqiang Mao, PhD · Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2023-09-01
Completion
2024-06-01

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05998733 on ClinicalTrials.gov