Registry of Multicenter Brain-Heart Comorbidity in China

Summary

This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. To establish a domestic multi-center, large-scale "brain-heart comorbidity" dynamic database platform including clinical, sample database, image and other multi-dimensional information requirements, through the construction of a multi-center intelligent scientific research integration platform based on artificial intelligence.

Any of newly diagnosed cardiovascular related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).

The data is stored on the brain-heart comorbidity warehouse via a physical server at the institution's data centre or a virtual hosted appliance. The brain-heart comorbidity platform comprises of a series of these appliances connected into a multicenter network. This network can broadcast queries to each appliance. Results are subsequently collected and aggregated. Once the data is sent to the network, it is mapped to a standard and controlled set of clinical terminologies and undergoes a data quality assessment including 'data cleaning' that rejects records which do not meet the brain-heart comorbidity quality standards. The brain-heart comorbidity warehouse performs internal and extensive data quality assessment with every refresh based on conformance, completeness, and plausibility (http://10.100.101.65:30080/login).

Conditions

• Ischemic Heart Disease
• Cardiac Arrest
• Atrial Fibrillation
• Heart Failure
• Aortic Diseases
• Subarachnoid Hemorrhage
• Intracerebral Hemorrhage
• Cerebral Infarction
• Occlusion and Stenosis of Precerebral Arteries
• Occlusion and Stenosis of Cerebellar Arteries
• Cerebral Aneurysm
• Moyamoya Disease
• Arteriovenous Malformation of Cerebral Vessels

Interventions

OTHER

Multi-disciplinary assessment

Multi-disciplinary assessment

Sponsors & Collaborators

• Beijing Tiantan Hospital

  lead OTHER

Principal Investigators

• Shuo Wang, MD · Beijing Tiantan Hospital

• Yong Cao, MD · Beijing Tiantan Hospital

• Dong Xu, MD · Beijing Tiantan Hospital

• Zening Jin, MD · Beijing Tiantan Hospital

• Hao Wang, MD · Beijing Tiantan Hospital

• Shuai Kang, MD · Beijing Tiantan Hospital

• Yu Chen, MD · Beijing Tiantan Hospital

• Qingyuan Liu, MD · Beijing Tiantan Hospital

• Runting Li, MD · Beijing Tiantan Hospital

• Heze Han, MD · Beijing Tiantan Hospital

• Wenxiong Song, MD · Beijing Tiantan Hospital

• Jionghao Xue, MD · Beijing Tiantan Hospital

• Minghao Liu, MD · Beijing Tiantan Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-01-01

Primary Completion

2032-12-31

Completion

2032-12-31

Countries

• China

Study Locations