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Impact of Reducing Colistin Use on Colistin Resistance in Humans and Poultry in Indonesia

NCT05960084 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 803

Last updated 2023-07-25

No results posted yet for this study

Summary

Colistin (polymyxin E) is considered a last resort antimicrobial for treatment of infections with multidrug- resistant bacteria, classified by WHO as 'highest prioritized, critically important for human medicine'. WHO suggests to ban or highly restrict its use in animals. In Indonesia, colistin resistance in human Escherichia coli isolates is poorly characterized as it requires specific non-routine tests. Presence of colistin resistance in E. coli in poultry resulted in a ban for livestock in Indonesia in 2020. However, colistin is still suspected to be routinely used in humans in multiple settings but the reasons for these practices are poorly understood. The ban on colistin use in livestock offers a unique opportunity to assess the impact of this intervention on colistin resistance in humans and animals, and how a One Health perspective can strengthen this intervention. This project aims to: i) determine phenotypic and genotypic colistin resistance in E. coli from humans and poultry in Indonesia; ii) assess the impact of the colistin ban on resistance in E. coli in animals and humans; iii) estimate the transmission of colistin resistance between animals and humans; iv) study colistin use and perceptions at the community level; and v) expand the initial colistin ban in the animal production sector into an integrative multi-sectorial One Health intervention, which will be designed and implemented using a community participatory approach. This project will provide a strong scientific basis to AMR policies in Indonesia, with great significance across Southeast Asia.

Conditions

Interventions

OTHER

screening

screening for colistin resistant E. coli

Sponsors & Collaborators

  • Indonesia University

    collaborator OTHER

  • Center For Indonesian Veterinary Analytical Studies

    collaborator UNKNOWN

  • Utrecht University

    collaborator OTHER

  • Institute of Tropical Medicine

    collaborator OTHER_GOV

  • University of Calgary

    collaborator OTHER

  • Directorate of Veterinary Public Health, Ministry of Agriculture

    collaborator UNKNOWN

  • Erasmus Medical Center

    lead OTHER

Principal Investigators

  • Anis Karuniawati, MD PhD · Indonesia University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-23
Primary Completion
2025-06-01
Completion
2025-06-01

Countries

  • Indonesia

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05960084 on ClinicalTrials.gov