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Effectiveness of Three Different Mouthrinses in Dental Plaque Control and Early Wound Healing

NCT03119831 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2017-08-24

Study results available
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Summary

Aim: This study compared the effectiveness of three different mouthrinses (alcohol and non-alcohol chlorhexidine, alkyl dimethyl glycine / alkyl dimethyl amine oxide - C31G) in plaque control and early wound healing, postoperatively.

Materials and Methods: In this, randomized, double-blind, controlled clinical trial 42 patients were allocated to three groups assigned to two weeks rinsing after periodontal surgery with C31G (group A), alcohol-free chlorhexidine 0.12% (group B) or alcohol-based chlorhexidine 0.12% (group C). At weeks 1 and 2, plaque and early wound healing indices were recorded. At day 14, total bacterial counts were estimated utilizing real - time qPCR. Statistics included linear and generalized linear mixed models.

Conditions

  • Periodontitis
  • Wound Healing

Interventions

DRUG

Alcohol-based Chlorhexidine Gluconate 0.12%

Rinsing with 15ml for one minute twice daily for 14 days

DRUG

Alcohol-free Chlorhexidine Gluconate 0.12%

Rinsing with 15ml for one minute twice daily for 14 days

DRUG

C31G

Rinsing with 15ml for one minute twice daily for 14 days

Sponsors & Collaborators

  • National and Kapodistrian University of Athens

    lead OTHER

Principal Investigators

  • Phoebus N Madianos, Professor · Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Greece

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
34 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-11-30
Primary Completion
2016-07-31
Completion
2016-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03119831 on ClinicalTrials.gov