MedTrace Logo

Troponin I Level and Mortality in Acute Abdominal Surgery

NCT05933837 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 341

Last updated 2023-07-06

No results posted yet for this study

Summary

The goal of this prospective cohort study is to estimate the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing acute high-risk abdominal surgery.

MINS is defined as at least one increased single measurement of plasma troponin I (TnI). TnI-dynamic is defined as either two succeeding measurements of TnI \> 59 ng/l with an increase/fall of more than 20%, or by one measurements of TnI \> 59 ng/l with a succeeding measurement of TnI \< 59 ng/l and a decrease of more than 50%.

Participants will have plasma TnI measured 6-12 hours postoperatively and on each of the following four postoperative days. Follow-up will be minimum one year after surgery.

The aim of the study is to determine:

* The incidence of MINS within the first four postoperative days
* The incidence of dynamic TnI changes
* The association between MINS and dynamic TnI changes respectively and all-course short-term mortality

Conditions

  • Myocardial Injury After Non-cardiac Surgery
  • Abdomen, Acute

Interventions

DIAGNOSTIC_TEST

Troponin I

Measurements of plasma Troponin I 6-12 hours and on the first four postoperative days after surgery.

Sponsors & Collaborators

  • Nordsjaellands Hospital

    lead OTHER

Principal Investigators

  • Claus A Bertelsen · Nordsjaellands Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-01
Primary Completion
2021-02-28
Completion
2022-02-28

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05933837 on ClinicalTrials.gov