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Combination Therapy of Different Antidepressants With Dietary Supplements

NCT05931965 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 88

Last updated 2023-09-11

No results posted yet for this study

Summary

The aim of this clinical trial is to compare the effect of antidepressants in combination with different dietary supplements in patients with depression. Our main objective is to compare the efficacy of antidepressants in combination with either L-methyl folate, Vit B12, or magnesium) in patients with depressive disorders. The levels of depressive symptoms as measured by the Patient Health Questionnaire (PHQ-9) at base level and during follow-up.

Conditions

Interventions

DIETARY_SUPPLEMENT

L-methylfolate

Participants receive L-methylfolate 400µg orally twice daily for 4 weeks

DIETARY_SUPPLEMENT

Vitamin B12

Participants receive mecobalamin 500µg intramuscularly stat on alternate days (6 total injections)

DIETARY_SUPPLEMENT

magnesium

Participants receive magnesium glycinate 400mg twice daily orally for 4 weeks (elemental 120mg approx.)

Sponsors & Collaborators

  • Riphah International University

    lead OTHER

Principal Investigators

  • Afifa Siddique, MBBS · IIMC-T, Riphah International University, Rawalpindi

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-05
Primary Completion
2023-07-30
Completion
2023-08-31

Countries

  • Pakistan

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05931965 on ClinicalTrials.gov