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Pathophysiologic Changes in the Respiratory System After Fire Smoke Inhalation

NCT01240707 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2016-09-27

No results posted yet for this study

Summary

Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. In this study the investigators will examine if the scope of inhalation injury can be assessed soon after hospital admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. At 6 months a lung function test and metacholine test will be performed to examine whether patients have developed increased bronchial hyperreactivity (asthma) or not after the initial fire smoke exposure.

Conditions

  • Bronchial Asthma

Interventions

OTHER

Fiberoptic bronchoscopy

Fiberoptic bronchoscopy performed to remove secretions and assess soot in central airways

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Espen R Nakstad, MD · Oslo University Hospital - Ulleval, Norway

  • Helge Opdahl, MD, PhD · Ullevaal University Hospital

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-11-30
Primary Completion
2016-05-31
Completion
2016-05-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01240707 on ClinicalTrials.gov