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High Flow Nasal Oxygen at Extubation for Adults Requiring a Breathing Tube for Treating Severe Breathing Difficulties

NCT05904652 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2

Last updated 2026-04-03

No results posted yet for this study

Summary

The goal of this feasibility study is to learn whether a new approach to breathing tube removal within the Intensive Care Unit is safe and acceptable to participants who require a breathing tube for the management of severe breathing difficulties. The main questions it aims to answer are:

* What is the recruitment rate to the study over 12 months?
* Is the study design acceptable and safe to participants?

Participants will receive high flow nasal oxygen before their breathing tube is removed. The investigators will compare this with standard practice of applying conventional, low-flow oxygen after the breathing tube removed to see if this effects the rate of repeat breathing tube insertion.

The investigators hypothesise that they will recruit 30 participants to the study protocol (15 participants in each group) over 12 months and that our study protocol will be tolerable and acceptable to participants.

Conditions

  • Respiratory Insufficiency

Interventions

DEVICE

Fisher and Paykel "HealthCare Airvo™ 3" high flow system

High Flow Nasal Oxygen Delivery Device

DEVICE

Conventional Oxygen Therapy

Low flow oxygen delivery device (Flow rate between 2 litres per minute and 15 litres per minute)

Sponsors & Collaborators

  • Fisher and Paykel Healthcare

    collaborator INDUSTRY

  • LINET

    collaborator UNKNOWN

  • NHS Greater Glasgow and Clyde

    lead OTHER

Principal Investigators

  • Malcolm AB Sim, MBChB, MD, FRCP, FRCA, FFICM · NHS Greater Glasgow and Clyde

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-11
Primary Completion
2024-09-10
Completion
2024-09-13

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05904652 on ClinicalTrials.gov