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Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)

NCT05903859 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-03-02

No results posted yet for this study

Summary

This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well. This study will determine if a medicine given by mouth will improve sperm motility in men with spinal cord injuries. The medicine is called probenecid.

Conditions

  • Infertility, Male

Interventions

DRUG

Probenecid 500 Milligrams (mg)

Participants in this group will receive 500 mg of probenecid by mouth twice a day for a total of 90 days.

DRUG

probenecid 250 Milligrams (mg)

Participants in this group will receive 250 mg of probenecid by mouth twice a day for a total of 90 days.

DRUG

Placebo

Participants in this group will receive a placebo pill by mouth twice a day for a total of 90 days.

Sponsors & Collaborators

  • Congressionally Directed Medical Research Programs

    collaborator FED

  • University of Miami

    lead OTHER

Principal Investigators

  • Emad Ibrahim, MD · University of Miami

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-18
Primary Completion
2027-05-31
Completion
2028-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05903859 on ClinicalTrials.gov