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The Role of Gut Microbiota in Children With Epilepsy Following Ketogenic Diet

NCT05898438 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-06-12

No results posted yet for this study

Summary

The role of human microbiota in neurological disorders via the "microbiota-gut-brain axis" is recently gaining increased attention due to the knowledge that gut microorganisms are involved in multiple gut and brain functions and metabolic pathways. The hypothesis of the present investigation is that changes of gut microbiota and their metabolic products may be a mechanism of the effectiveness of ketogenic diet in epilepsy.

The aim of the present study is to investigate the changes of gut microbiota induced by the ketogenic diet and if certain populations of microorganisms are associated with better seizure control in epileptic children.

This is a non-interventional study that will include epileptic children 2-18 years old eligible for ketogenic diet. The gut microbiome of participants will be examined in stools before and three months after the implementation of an olive oil- based ketogenic diet therapy. One of the participants' parents will also be included providing fecal sample for the examination of gut microbiome.

Conditions

Sponsors & Collaborators

  • Harokopio University

    collaborator OTHER

  • Attikon Hospital

    lead OTHER

Principal Investigators

  • Argirios Dinopoulos, Professor · 3rd Pediatric Clinic, Attikon Athens University Hospital

Eligibility

Min Age
2 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-12-18
Primary Completion
2023-12-31
Completion
2024-12-31

Countries

  • Greece

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05898438 on ClinicalTrials.gov