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In Line Aerosol Nebulization With High Flow

NCT05880836 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-08-11

No results posted yet for this study

Summary

The objective of ILAN is to assess the safety, feasibility and bronchodilator efficacy of in-line bronchodilator nebulizer delivery with VMN via HFNC system in hypoxemic respiratory failure patients treated with bronchodilators and compare this method to standard-nebulization using a jet nebulizer with a facial mask. The investigators hypothesized that aerosol nebulization using HFNC/VMN represents safer and more convenient approach in hypoxemic respiratory failure patients in comparison to conventional therapy while providing similar bronchodilator efficacy.

Conditions

  • Hypoxemic Respiratory Failure
  • Airway Obstruction

Interventions

DEVICE

nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen

nebulized delivery of bronchodilator via in-line drug delivery maintaining high-flow nasal cannula oxygen

DEVICE

standard jet nebulization (SJN) with face mask

standard jet nebulization delivery of bronchodilator

Sponsors & Collaborators

Principal Investigators

  • Igor Barjaktarevic, MD, PhD · University of California, Los Angeles

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2025-01-01
Completion
2025-01-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05880836 on ClinicalTrials.gov