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Assessment of Airway Obstruction in Infants With Lower Respiratory Infections

NCT00435994 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 59

Last updated 2016-06-01

Study results available
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Summary

The purpose of this study is to evaluate how two different aerosol medications may improve airway function in infants with respiratory illness. We are using two different medications and comparing the difference in lung function after each medication. We will also be taking a nasal wash sample for VEGF. We will be using this in comparing how infants respond to the aerosol medications as well. We hope to help standardize medications used for infants with bronchiolitis and RSV.

Conditions

  • Bronchiolitis
  • Respiratory Syncytial Virus Infections

Interventions

DRUG

Inhaled primatene will be given as a breathing treatment

While the research subject is sedated an inhaled mist of primatene mist will be given to the patient.

OTHER

Nasal Washing

1-3 mls of normal saline will be instilled into the infant's nose and then aspirated to obtain the nasal fluid, which will be analyzed for VEGF level by ELISA and viral antigens by immunoflourescence

Sponsors & Collaborators

  • Thrasher Research Fund

    collaborator OTHER

  • Indiana University School of Medicine

    lead OTHER

Principal Investigators

  • Robert S. Tepper, MD · Indiana University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
2 Months
Max Age
2 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-12-31
Primary Completion
2009-03-31
Completion
2012-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00435994 on ClinicalTrials.gov