Effect of Renin Angiotensin Aldosterone System Genetic Polymorphism on the Pharmacological Effect of Mineralocorticoid Receptor Antagonists in Patients With Myocardial Infarction
NCT05873400 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 102
Last updated 2023-05-24
Summary
Early treatment of Myocardial Infarction patients with mineralocorticoid receptor antagonist with help reduces the incidence of cardiac remodeling and development into heart failure. Also studying aldosterone synthase (CYP11B2) and mineralocorticoid receptor (NR3C2) gene polymorphisms in Egyptian Myocardial Infarction patients will help tailor medication therapy and optimize therapeutic effects with the least adverse effects.
Conditions
Sponsors & Collaborators
-
Ain Shams University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-08-01
- Primary Completion
- 2023-12-01
- Completion
- 2024-04-01
Countries
- Egypt
Study Locations
More Related Trials
-
MR Antagonist and LSD1
NCT04840342 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
The Role of Mineralocorticoid Receptors in Vascular Function
NCT00759525 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function
NCT00405639 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
The Effect of RAAS Blockers on ACE2 Levels
NCT05418361 ·Status: COMPLETED
-
Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension
NCT00005394 ·Status: COMPLETED
-
Diurnal Variation of Plasminogen Activator Inhibitor-1
NCT00515021 ·Status: COMPLETED ·Phase: PHASE4
-
Aldosterone Antagonism in Diastolic Heart Failure
NCT00108251 ·Status: COMPLETED ·Phase: PHASE4
-
Mineralocorticoid Antagonism and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
NCT01853553 ·Status: COMPLETED ·Phase: PHASE3
-
Add-on Aliskiren Treatment in Patients With Chronic Congestive Heart Failure
NCT01040494 ·Status: UNKNOWN ·Phase: PHASE4
-
Aldosterone Blockade to Prevent Myocardial Remodeling In Patients With Controlled Essential Hypertension
NCT00980031 ·Status: TERMINATED ·Phase: NA
-
The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography
NCT03329443 ·Status: COMPLETED ·Phase: PHASE2
-
Larger Dose of Spironolactone for the Treatment of Patients With Nonischemic Cardiomyopathy
NCT00125437 ·Status: TERMINATED ·Phase: NA
-
Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia
NCT05688579 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE4
-
Spironolactone in Patients With Single Ventricle Heart
NCT00211081 ·Status: COMPLETED ·Phase: NA
-
Aldosterone and Vascular Disease in Diabetes Mellitus
NCT00214825 ·Status: COMPLETED ·Phase: NA
-
Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity
NCT04519164 ·Status: COMPLETED ·Phase: PHASE4
-
Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension
NCT05925569 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Hemodynamic Effects of Spironolactone in Patients With Heart Failure
NCT00860340 ·Status: COMPLETED ·Phase: NA
-
Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria
NCT02040441 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study
NCT06108427 ·Status: RECRUITING ·Phase: NA
-
Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy
NCT01893788 ·Status: UNKNOWN ·Phase: PHASE4
-
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.
NCT00405548 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
The Effect of Amiloride and Spironolactone in Patients With Hypertension
NCT01388088 ·Status: COMPLETED ·Phase: PHASE4
-
The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production
NCT02871648 ·Status: COMPLETED ·Phase: PHASE1
-
Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease
NCT00865501 ·Status: COMPLETED ·Phase: PHASE3