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Profile of Dysphagia in Myotonic Dystrophy Type 1 (DM1)

NCT05865483 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 177

Last updated 2025-08-19

No results posted yet for this study

Summary

The goal of this observational study is to learn about swallowing difficulties (dysphagia) in patients living with myotonic dystrophy type 1 (DM1). The main questions it aims to answer are:

* whether the size and structure of the muscles involved in swallowing differ to those without the disease
* how the size and structure of muscles may associate with swallowing function and swallowing symptoms in this group.

Participants will undergo a range of tests including:

* Ultrasound (US) assessment of the muscles involved in swallowing
* An x-ray swallowing study (known as videofluoroscopy)
* Assessment of swallowing symptoms, including questionnaires
* Assessments of mobility, activity and breathing
* Assessments of quality of life and wellbeing

Conditions

  • Myotonic Dystrophy 1
  • Dysphagia, Oropharyngeal

Sponsors & Collaborators

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • Myotonic Dystrophy Support Group, United Kingdom

    collaborator UNKNOWN

  • The National Brain Appeal, The National Hospital for Neurology and Neurosurgery

    collaborator UNKNOWN

  • University College, London

    lead OTHER

Principal Investigators

  • Stuart Taylor, PhD · University College London & University College London Hospitals

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-03
Primary Completion
2024-08-23
Completion
2024-08-23

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05865483 on ClinicalTrials.gov