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The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients

NCT05858320 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 225

Last updated 2026-01-16

No results posted yet for this study

Summary

The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed medical therapy (GDMT) optimization in HFrEF patients. Eligible participants will be randomized to the web application intervention or control in a 1:1 manner, stratified by site.

The intervention is an adaptive medication optimization web application that extracts and analyzes the EHR data with a computable medication optimization algorithm. The algorithm provides a medication quality score and outputs medication optimization recommendations written in a patient -friendly manner.

Conditions

Interventions

OTHER

SmartHF application

Adaptive medication recommendations that can be shared with the participants HF provider.

Sponsors & Collaborators

  • Washington University, Barns Jewish Hospital, St. Louis, MO

    collaborator UNKNOWN

  • Henry Ford Hospital, Detroit, MI

    collaborator UNKNOWN

  • Emory University, Grady Hospital, Atlanta, GA

    collaborator UNKNOWN

  • University of Michigan

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-21
Primary Completion
2025-12-01
Completion
2025-12-01

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05858320 on ClinicalTrials.gov