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Effect of Pomanox® on Skin Ageing (POMASKIN)

NCT05842447 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 66

Last updated 2024-10-30

No results posted yet for this study

Summary

The state of skin health impacts not only on the general health of individuals, but also on mental health. Ultraviolet radiation (UV) is one of the main external factors that causes skin ageing, producing photo-aging, characterized by multiple alterations in the skin such as the appearance of wrinkles, dryness, erythema, alterations in the pigmentation, inflammation and increased fragility.

Several studies show that polyphenols extracts, including pomegranate extracts, have beneficial effects on various skin characteristics induced by photoaging by modulating internal factors that lead to changes associated with photoaging. Among these internal factors are oxidative stress, glycation stress caused by an accumulation of advances glycation end-products (AGEs), inflammation, and the composition of the intestinal and skin microbiota.

Pomanox® is a polyphenolic extract derived from pomegranate for which antioxidant activity and positive effects on the metabolism of collagen and hyaluronic acid have been shown in previous in vitro studies.

Conditions

  • Skin Ageing

Interventions

DIETARY_SUPPLEMENT

367 mg Pomanox group

Treatment with 367 mg Pomanox®P30 during 12 weeks

DIETARY_SUPPLEMENT

700 mg Pomanox group

Treatment with 700 mg Pomanox®P30 during 12 weeks

DIETARY_SUPPLEMENT

Control group

Treatment with maltodextrin during 12 weeks

Sponsors & Collaborators

  • Euromed, S.A.

    collaborator UNKNOWN

  • Fundació Eurecat

    lead OTHER

Principal Investigators

  • Antoni Caimari, PhD · Fundació Eurecat

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-16
Primary Completion
2024-03-05
Completion
2024-10-28

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05842447 on ClinicalTrials.gov