Microvascular Cardiac Allograft Vasculopathy Trial

Summary

The aim of the mCAV study is a comprehensive characterization of the genetic, morphological and functional phenotype of isolated microvascular graft vasculopathy (mCAV) after orthotopic heart transplantation (OHT).

The utilized methods include dynamic echocardiography, magnetic resonance imaging, invasive microvascular resistance measurements, histology, cellular calcium-signaling and magnetocardiography as well as molecular genetic expression analysis (miRNA based).

Conditions

• Cardiac Allograft Vasculopathy

Interventions

DIAGNOSTIC_TEST

Echocardiography

Echocardiography with afterload change

DIAGNOSTIC_TEST

Magnetic resonance imaging

Stress-MRI

DIAGNOSTIC_TEST

Magnetocardiography

Magnetocardiography

DIAGNOSTIC_TEST

Histology

Histological analysis

DIAGNOSTIC_TEST

Genetics

miRNA sequencing

DIAGNOSTIC_TEST

calcium signaling

cardiomyocyte calcium signaling

DIAGNOSTIC_TEST

IMR

Index of microvascular resistance measurement

DIAGNOSTIC_TEST

Angio-IMR

Angiography derived post-processing index if microvascular resistance

Sponsors & Collaborators

• Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

  collaborator OTHER

• Deutsche Stiftung für Herzforschung

  collaborator OTHER

• German Heart Institute

  lead OTHER

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-10-01

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• Germany

Study Locations