MedTrace Logo

Gut Microbiota: a Player in Chronic Pain in Patients With Rheumatoid Arthritis?

NCT05822856 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 125

Last updated 2023-09-13

No results posted yet for this study

Summary

Although rheumatoid arthritis (RA) treatments are very effective in reducing inflammation, chronic pain persists in 20 to 30% of patients.

The intestinal microbiota can participate on the pain pathways and a decrease in Faecalibacterium has been associated with chronic pain and chronic fatigue. RA patients have an altered gut microbiota or dysbiosis. Among the bacteria that are most often differentially represented between RA and control, Faecalibacterium, was also found less abundant in RA patients.

The composition of the gut microbiota has never been evaluated in relation to the clinical phenotype of RA patients and in particular to the presence of a diffuse pain. In this study, investigators will test whether the gut microbiota of RA patients, and in particular the decrease of Faecalibacterium, would promote pain sensitization phenomena, and thus, chronic pain despite the control of joint inflammation.

Conditions

Interventions

OTHER

Blood sampling and others interventions

Blood sampling, faeces collection, questionnaires, tactile sensitivity, sensorial tests

Sponsors & Collaborators

  • University Hospital, Montpellier

    lead OTHER

Principal Investigators

  • Claire I DAIEN, MD-PhD · Centre Hospitalier Universitaire de Montpellier Montpellier

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-06
Primary Completion
2024-11-30
Completion
2024-11-30

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05822856 on ClinicalTrials.gov