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Oxygen Dissociation Curve in Patients Undergoing Orthotopic Liver Transplantation

NCT05822570 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-03-26

No results posted yet for this study

Summary

Hemoglobin (Hb) is the molecule responsible for the transport of oxygen (O2) to the tissues in mammals.

The p50 and the Hill coefficient (HC) best describe the ODC. The interaction between Hb and O2 can be influenced by many agents and conditions like temperature, pH, pCO2 and 2,3-diphosphoglycerate (2,3-DPG).

During liver transplantation numerous profound physiological changes occur, linked to the different stages of the surgical procedure.

Previous studies in humans and animals undergoing liver transplantation have shown that while the ODC seems preserved during preparation and the anhepatic phase, a left shift of the ODC occurs after reperfusion . This left shift of the ODC could imply a decreased release of oxygen to the tissues, probably worsening hemodynamic instability.

With this pilot study the investigator aim to measure ODCs at baseline and at different stages during orthotopic liver transplantation in patients in order to get deeper understanding of oxygen delivery and supply during liver transplantation surgery.

Conditions

  • Liver Transplantation

Interventions

DIAGNOSTIC_TEST

Assessment of Oxygen Dissociation Curve (ODC)

ODC will be assessed at 5 timepoints: T0 after installation of arterial catheter, T1 before clamping of the liver, T2 5-10 min before reperfusion of the liver graft, T3 45 min after reperfusion, T4 1 h after T3 or at end of surgery

Sponsors & Collaborators

  • Medical University Innsbruck

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-01
Primary Completion
2024-09-30
Completion
2024-10-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05822570 on ClinicalTrials.gov