ctDNA-MRD in Stage IIIB-C NSCLC Patients Treated With Induction Chemoimmunotherapy
NCT05822284 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50
Last updated 2023-04-20
Summary
The goal of this observational study is to explore whether ctDNA-MRD dynamic monitoring can more effectively predict the therapeutic effect of induction chemoimmunotherapy followed by surgery or non-surgical treatment for stage IIIB-C driver-negative NSCLC in the MDT model, so as to accurately guide clinical diagnosis and treatment.
Conditions
Interventions
- DIAGNOSTIC_TEST
-
NGS and ctDNA-MRD detection
NGS and ctDNA-MRD detection
Sponsors & Collaborators
-
Geneplus-Beijing Co. Ltd.
collaborator INDUSTRY -
Second Xiangya Hospital of Central South University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-04-30
- Primary Completion
- 2029-03-31
- Completion
- 2029-03-31
Countries
- China
Study Locations
More Related Trials
-
ctDNA as a Biomarker for Treatment in Advanced NSCLC
NCT05486988 ·Status: UNKNOWN
-
ctDNA Dynamic Monitoring and Its Role of Prognosis in Stage I NSCLS by NGS
NCT03172156 ·Status: COMPLETED
-
MRD-guided Prognosis Prediction and Adjuvant Treatment Based on CTC and ctDNA in NSCLC
NCT06198868 ·Status: RECRUITING
-
NGS-based Comprehensive Genomic ctDNA Panel in NSCLC With Immunotherapy
NCT04636047 ·Status: UNKNOWN
-
Evaluation ctDNA in Patients of Non-Small-Cell Lung Cancer Following Resection
NCT04238130 ·Status: COMPLETED
-
Significance of MRD After Surgery in Driver Gene-positive and Driver Gene-negative Stage IB-IIA NSCLC
NCT05441566 ·Status: ENROLLING_BY_INVITATION
-
Dynamic Changes of Circulating Tumor DNA in Late Stage NSCLC Patients
NCT02804100 ·Status: UNKNOWN
-
Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
NCT06358222 ·Status: RECRUITING
-
Chromosomal Instability as a Surrogate Biomarker of Drug Resistance in Immunotherapy for Lung Cancer Patients
NCT04203095 ·Status: UNKNOWN
-
MRD Monitoring in Lung Cancer After Resection
NCT04976296 ·Status: RECRUITING
-
Clinical Sensitivity Verification Study of Circulating Tumor Cells Gene Mutation Detection From Advanced NSCLC Patients
NCT04229121 ·Status: UNKNOWN
-
Non-Invasive ctDNA Methylation Detection for Lung Nodule Patients
NCT03685669 ·Status: UNKNOWN
-
Application of Methylation Markers in Early Detection and MRD Monitoring of Lung Cancer
NCT07257458 ·Status: RECRUITING
-
Diagnostic and Monitoring Significance of ctDNA Methylation Analysis by NGS in Benign and Malignant Pulmonary Nodules
NCT03651986 ·Status: UNKNOWN
-
Significance of MRD Monitoring in Patients With Potentially Resectable Stage III Non-small Cell Lung Cancer
NCT06081777 ·Status: RECRUITING
-
An Exploratory Study of ctDNA-MRD in Predicting the Efficacy of Esophageal Squamous Cell Carcinoma
NCT05759325 ·Status: NOT_YET_RECRUITING
-
The Role of ctDNA Testing Plus AI-based Pathology in Resectable LSCC
NCT05778253 ·Status: RECRUITING
-
Circulating Tumor DNA in Surgical Lung Cancer Patients
NCT03081741 ·Status: UNKNOWN
-
Comparison of Circulating Tumor DNA and Tumor Tissue DNA by Targeted Sequencing in Non-Small Cell Lung Cancer
NCT02645318 ·Status: COMPLETED
-
Dynamic Monitoring Circulating Tumor DNA in Surgical Patients With Lung Cancer
NCT03317080 ·Status: UNKNOWN
-
A Prospective Study to Evaluate the Consistency of Next-Generation Sequencing(NGS)-Panels by Using Malignant Hydrothorax Form NSCLC
NCT03546452 ·Status: UNKNOWN
-
Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Stage III NSCLC
NCT06111807 ·Status: RECRUITING
-
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
NCT05415670 ·Status: COMPLETED
-
Exploration of Predictive Markers of Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer
NCT05965557 ·Status: RECRUITING
-
Circulating Tumor DNA Longitudinal Monitoring in Stage III-IV Lung Cancer Patients
NCT03664843 ·Status: UNKNOWN