MRD Monitoring in Lung Cancer After Resection
NCT04976296 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300
Last updated 2022-03-17
Summary
The conception of molecular residual disease (MRD) extending from hematologic tumor to solid tumors. Evidences supporting MRD evaluation for lung cancer by liquid biopsy has gradually accumulated, especially circulating tumor DNA (ctDNA). In this observational study, the investigators prospectively enroll stage I-IIIA non-small cell lung cancer (NSCLC) patients who underwent complete resection. Preoperative blood sample, tumor tissue and dynamic postoperative blood samples are collected continuously for MRD detection. This study aim to explore the prognostic value of MRD for stage I-IIIA NSCLC patients after complete resection.
Conditions
Interventions
- DIAGNOSTIC_TEST
-
MRD detection
The Geneplus OncoMRD lung assay is used to detect the MRD status.
Sponsors & Collaborators
-
Guangdong Provincial People's Hospital
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-09-01
- Primary Completion
- 2027-12-30
- Completion
- 2027-12-30
Countries
- China
Study Locations
More Related Trials
-
Evaluation ctDNA in Patients of Non-Small-Cell Lung Cancer Following Resection
NCT04238130 ·Status: COMPLETED
-
ctDNA Dynamic Monitoring and Its Role of Prognosis in Stage I NSCLS by NGS
NCT03172156 ·Status: COMPLETED
-
ctDNA-MRD in Stage IIIB-C NSCLC Patients Treated With Induction Chemoimmunotherapy
NCT05822284 ·Status: NOT_YET_RECRUITING
-
Residual Disease Evaluation of Resected NSCLC by cirDNA Analysis
NCT05165160 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Precision Diagnosis for Intraoperative Frozen Section of Early Stage Lung Cancer
NCT02941003 ·Status: UNKNOWN ·Phase: NA
-
Significance of MRD Monitoring in Patients With Potentially Resectable Stage III Non-small Cell Lung Cancer
NCT06081777 ·Status: RECRUITING
-
Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
NCT05254782 ·Status: RECRUITING
-
Liquid Biopsy in Advanced Oligometastatic NSCLC Receiving Surgery
NCT05648370 ·Status: UNKNOWN
-
Dynamic Monitoring Circulating Tumor DNA in Surgical Patients With Lung Cancer
NCT03317080 ·Status: UNKNOWN
-
MRD-guided Prognosis Prediction and Adjuvant Treatment Based on CTC and ctDNA in NSCLC
NCT06198868 ·Status: RECRUITING
-
ctDNA Dynamic Monitoring and Its Role of Prognosis in Stage II to IIIA NSCLC by NGS
NCT03465241 ·Status: COMPLETED
-
A Study of Molecular Residual, Dynamic Monitoring and Recurrence of Stage III Driver Mutated NSCLC
NCT06443684 ·Status: RECRUITING
-
Perioperative and Postoperative Circulating Tumor Cell Monitoring in Different Stage of NSCLC
NCT07186855 ·Status: COMPLETED
-
Biomarkers for Diagnosis of Lung Cancer
NCT02050100 ·Status: COMPLETED
-
The Use of Molecular Radiogenomics in Non-small Cell Lung Cancer
NCT05541744 ·Status: RECRUITING
-
Application of Methylation Markers in Early Detection and MRD Monitoring of Lung Cancer
NCT07257458 ·Status: RECRUITING
-
Biomarker Discovery in Lung Cancer - Malaysia
NCT06504927 ·Status: RECRUITING
-
Dynamic Changes of Circulating Tumor DNA in Surgical Lung Cancer Patients
NCT02965391 ·Status: COMPLETED
-
Application Research of Methylation Markers in Early-stage Lung Cancer Patients Treated With Co-ablation System Therapy
NCT07257471 ·Status: RECRUITING
-
Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Stage III NSCLC
NCT06111807 ·Status: RECRUITING
-
The Accuracy of Targeted Lymph Node Dissection of Non-small Cell Lung Cancer Patients According to Predictive Models
NCT06768853 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
NCT06252129 ·Status: RECRUITING ·Phase: NA
-
To Establish a Molecular Typing System for Early Diagnosis of Lung Cancer
NCT05432128 ·Status: RECRUITING
-
Construction and Evaluation of the Liquid Biopsy-based Early Diagnostic Model for Lung Cancer
NCT04156360 ·Status: UNKNOWN
-
Prognostic Significance of the Uncertain Resection in NSCLC
NCT06511661 ·Status: ACTIVE_NOT_RECRUITING