Diagnostic and Monitoring Significance of ctDNA Methylation Analysis by NGS in Benign and Malignant Pulmonary Nodules

Summary

AnchorDx is using circulating tumor DNA (ctDNA) methylation analysis by next-generation sequencing (NGS) to develop a blood-based assay for differentiating benign and malignant pulmonary nodules early. The purpose of this study is to evaluate the diagnostic performance of this assay in patients with pulmonary nodules.

Conditions

• Pulmonary Nodules

Interventions

DIAGNOSTIC_TEST

ctDNA methylation analysis by NGS

A blood-based assay for differentiating benign and malignant pulmonary nodules early using circulating tumor DNA (ctDNA) methylation analysis by next-generation sequencing (NGS)

Sponsors & Collaborators

• Xiangya Hospital of Central South University

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• Shanghai Zhongshan Hospital

  collaborator OTHER

• Shanghai Pulmonary Hospital affiliated to Tongji University

  collaborator UNKNOWN

• First Hospital of China Medical University

  collaborator OTHER

• Guizhou Provincial People's Hospital

  collaborator OTHER

• Shanghai Chest Hospital

  collaborator OTHER

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• Inner Mongolia People's Hospital

  collaborator OTHER

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Second Hospital of Jilin University

  collaborator OTHER

• LanZhou University

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• The First People's Hospital of Yunnan

  collaborator OTHER

• Shantou Affiliated Hospital of Sun Yat-Sen University

  collaborator UNKNOWN

• Ruijin Hospital

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• The First Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• The First Affiliated Hospital of Air Force Medicial University

  collaborator OTHER

• Shenzhen People's Hospital

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• Beijing Chao Yang Hospital

  collaborator OTHER

• Xiamen Second Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• AnchorDx Medical Co., Ltd.

  lead INDUSTRY

Principal Investigators

• Nanshan ZHONG, MD · The First Affiliated Hospital of Guangzhou Medical University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-11-26

Primary Completion

2024-09-30

Completion

2025-06-30

Countries

• China

Study Locations