MedTrace Logo

ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks

NCT05820490 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2026-04-15

No results posted yet for this study

Summary

The purpose of this study is to determine the impact of real-world shiftwork on metabolic flexibility.

Conditions

  • Metabolic Health

Interventions

OTHER

Whole Room Calorimeter

The indirect calorimetry system allows your oxygen / carbon dioxide exchange to be measured, thereby showing the number of calories burned.

OTHER

Mixed-Meal Tolerance Test (MMTT)

The MMTT is done to measure how much body handles a mixed meal.This test shake will raise blood sugar and cause the body to produce insulin.

OTHER

Core Body Temperature

Participants will be asked to swallow a core body temperature monitor prior to entering the whole room calorimeter. This monitor is used to record participants core body temperature.

OTHER

Morningness-Eveningness Questionnaire

Participants will fill out a questionnaire that asks about your preference for morning or evening.

PROCEDURE

Muscle Biopsy

Participants will have two skeletal muscle biopsies (one in the evening and one in the morning). This procedure is used to sample muscle cells from the right and left leg Vastus Lateralis (thigh) muscle.

OTHER

Serial Blood Sampling

Participants will have blood sampled every hour for 24 hours to assess changes in circulating hormones.

Sponsors & Collaborators

  • AdventHealth Translational Research Institute

    lead OTHER

Principal Investigators

  • Melissa Erickson, PhD · Study Principal Investigator

Eligibility

Min Age
21 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-28
Primary Completion
2026-01-31
Completion
2026-01-31

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05820490 on ClinicalTrials.gov