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Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)

NCT05814640 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 520

Last updated 2026-01-27

No results posted yet for this study

Summary

This project aims to investigate the effectiveness of existing common antidepressants and to provide new evidence for depressed children and adolescents who are not responding to their first treatment.

Conditions

Interventions

DRUG

Fluoxetine

Commonly used oral antidepressant.

DRUG

Sertraline

Commonly used oral antidepressant.

DRUG

Vortioxetine

Commonly used oral antidepressant.

DRUG

Duloxetine

Commonly used oral antidepressant.

DRUG

Aripiprazole

Commonly used oral augmentation therapy for antidepressants

DRUG

Lithium Carbonate

Commonly used oral augmentation therapy for antidepressants.

DRUG

Olanzapine

Commonly used oral augmentation therapy for antidepressants.

BEHAVIORAL

GCBT

Commonly used intervention therapy of psychotherapy.

Sponsors & Collaborators

  • The Second Affiliated Hospital of Chongqing Medical University

    collaborator OTHER

  • Second Xiangya Hospital of Central South University

    collaborator OTHER

  • Children's Hospital of Chongqing Medical University

    collaborator OTHER

  • First Affiliated Hospital of Chongqing Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
SEQUENTIAL

Eligibility

Min Age
13 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-20
Primary Completion
2026-12-31
Completion
2027-07-01

Countries

  • China

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05814640 on ClinicalTrials.gov