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Pathology in the Brain After mTBI - A Multimodal MRI Study

NCT01936792 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2015-04-21

No results posted yet for this study

Summary

The purpose is to use Diffusion Kurtosis Imaging (DKI), Diffusion Tensor Imaging (DTI) and resting state functional MRI to examine tissue damage in the brains of people who have had a concussion, both acute and 3 months after the accident. A secondary purpose is to examine whether the results of the scans are associated with physical, cognitive and emotional problems after concussion.

It is hypothesized that there will be a change in the diffusion signal measured with DKI in the thalamus (THA) and with DTI in the corpus callosum (CC), in the acute stage and at follow-up of the mTBI subjects compared with the healthy controls. Secondary it is expected that there will be changes in the diffusion signal measured with DKI and DTI in other WM and GM area in both the acute stage and at follow up with mTBI subjects compared with healthy controls. Also rs-fMRI markers are secondary expected to differ in the two groups. Moreover secondarily the MRI markers are tested for correlation with the severity of PCS acutely and at follow up after mTBI.

Conditions

  • Concussion

Sponsors & Collaborators

  • Regionshospitalet Hammel Neurocenter

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Jørgen F Nielsen, Professor · Region Hospital, Hammel Neurocenter, University Clinic, Voldbyvej 15, 8450 Hammel

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-08-31
Primary Completion
2015-04-30
Completion
2015-04-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01936792 on ClinicalTrials.gov