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Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children

NCT05807555 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2024-05-03

No results posted yet for this study

Summary

The Autonomic Nervous System (ANS) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions.

Many studies have investigated induced stimulation of the vagus nerve and its therapeutic effect in inhibiting TNFα (Tumor Necrosis Factor alpha) secretion, and therefore the risk of hypotension, septic shock, organ dysfunction during inflammation.

While the anti-inflammatory effect of the autonomic nervous system on inflammation has been well studied, conversely, the effect of major inflammation on the balance of the autonomic nervous system is more difficult to understand. The inflammatory reflex could be overwhelmed and the regulatory centers of the brainstem dysregulated during situations of extreme inflammation.

Conditions

  • Sepsis
  • Autonomic Nervous System

Interventions

OTHER

Ambulatory ECG

24h ECG monitoring

BIOLOGICAL

Blood sample

The usual biological tests necessary for the management of the child and the addition of 1 tube of 2 ml

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • HUGUES PATURAL, MD-PHD · CHU DE SAINT-ETIENNE

Eligibility

Min Age
1 Day
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-29
Primary Completion
2025-01-01
Completion
2025-01-01

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05807555 on ClinicalTrials.gov