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Screening and Identification of Biomarkers for High Myopia by a Rapid Method

NCT05803174 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2023-04-07

No results posted yet for this study

Summary

To screen and identify sensitive biomarkers for high myopia via a robust, convenient, and cost-effective approach according to the association between high myopia and concentration of biomarkers in tear fluid, saliva and blood among adults and children.

Conditions

  • High Myopia

Interventions

DIAGNOSTIC_TEST

blood sample

Blood collection Circulating serum concentrations of melatonin and dopamine were determined from fasting blood samples. Participants were required to fast from 10 pm the previous evening. A 5 mL serum blood sample was collected from the antecubital vein between 8.30 am and 10 am. Tear collection Tear samples were collected using Schirmer's strip without anesthesia between 8:30-10:00am. Tears were extracted in 200 μl of 1 X Phosphate Buffered Saline with 0.1% Tween-20 (PBST). Saliva collection Saliva samples were collected via the "passive drool" method with subjects in a seated position. Subjects were asked to rinse their mouth with water 10 minutes prior to saliva collection and to refrain from using lip makeup during the sampling period.

Sponsors & Collaborators

  • Tsinghua University

    collaborator OTHER

  • Beijing Tongren Hospital

    lead OTHER

Principal Investigators

  • Shi-Ming Li · Beijing Tongren Hospital

Eligibility

Min Age
6 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-20
Primary Completion
2023-05-31
Completion
2023-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05803174 on ClinicalTrials.gov