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Clinical and Genetic Studies in Families With Myopia and Related Diseases

NCT00272376 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 851

Last updated 2019-12-12

No results posted yet for this study

Summary

This study will examine the inheritance of myopia in families of various nationalities and ethnic backgrounds to identify gene changes that cause myopia or similar diseases and to better understand these conditions. In patients with myopia, the eye does not focus light accurately on the retina (tissue that lines the back of the eye), so that objects at a distance appear blurry. Myopia may occur alone, with other vision problems such as retinal dislocations, cataract or glaucoma, or with other problems such as joint or skin problems.

People with myopia (usually those from families with several affected members) and control subjects with normal vision may be eligible for this study.

Each participant undergoes the following procedures:

* Blood draw for genetic testing related to the disorders under study
* Medical and family history, including drawing a family tree to explore vision problems in the family
* Complete eye examination, including refraction (pupil dilation) and visual acuity testing, photographs of the retina and possibly lens, and specialized tests to measure field of vision, color vision and ability to see in the dark

Conditions

  • Myopia

Sponsors & Collaborators

  • National Eye Institute (NEI)

    lead NIH

Principal Investigators

  • James F Hejtmancik, M.D. · National Eye Institute (NEI)

Eligibility

Min Age
4 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-12-21
Completion
2016-07-29

Countries

  • United States
  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00272376 on ClinicalTrials.gov