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Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

NCT05802888 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 260

Last updated 2023-04-07

No results posted yet for this study

Summary

The researchers collect H.pylori-positive patients who need rescue therapy from the outpatient clinic. The subjects were randomized to receive a dose and frequency of tetracycline 500mg tid or qid of bismuth quadruple eradication therapy. 6-8 weeks after treatment, the subjects will re-take the 13C-urea breath test. Calculate the eradication rates, adverse reaction rates and patient compliance of each group.

Conditions

  • Helicobacter Pylori Infection

Interventions

DRUG

Tetracycline 500mg tid

Amoxicillin 1000mg bid +Tetracycline 500mg tid +Bismuth+Esomeprazole 40mg bid

DRUG

Tetracycline 500mg qid

Amoxicillin 1000mg bid +Tetracycline 500mg qid +Bismuth+Esomeprazole 40mg bid

Sponsors & Collaborators

  • Peking University Care Luzhong Hospital

    collaborator OTHER

  • Zibo Central Hospital

    collaborator OTHER_GOV

  • Yuncheng County Hospital of Traditional Chinese Medicine

    collaborator UNKNOWN

  • Taierzhuang District People's Hospital

    collaborator OTHER

  • People's Hospital of Zhengzhou University

    collaborator OTHER

  • Shandong University

    lead OTHER

Principal Investigators

  • Yanqing Li, Ph.D · Qilu Hospital of Shandong University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-12
Primary Completion
2024-06-15
Completion
2024-06-15

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05802888 on ClinicalTrials.gov