P-CABs-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication

Summary

Bismuth-containing quadruple therapy was recommended as a first-line treatment for Helicobacter pylori infection. This study aimed to compare real-world outcomes of various potassium-competitive acid blockers (P-CABs) -based bismuth quadruple regimens and identify factors influencing treatment failure. A multicenter cohort study was conducted and study outcomes included eradication rates and incidence of adverse events.

Conditions

• Helicobacter Pylori Infection

Interventions

OTHER

Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures

Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures.

Sponsors & Collaborators

• Qilu Hospital of Shandong University

  collaborator OTHER

• Feicheng People's Hospital

  collaborator UNKNOWN

• Binzhou Maternal and Child Health Hospital

  collaborator UNKNOWN

• Jinxiang County People's Hospital

  collaborator UNKNOWN

• The People's Hospital of Jimo

  collaborator UNKNOWN

• Zibo Maternal and Child Health Hospital

  collaborator UNKNOWN

• Yantai Penglai Traditional Chinese Medicine Hospital

  collaborator UNKNOWN

• Zaozhuang Municipal Hospital

  collaborator OTHER

• Linyi Yizhou Hospital

  collaborator UNKNOWN

• Taierzhuang District People's Hospital

  collaborator OTHER

• Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• Yuncheng Traditional Chinese Medicine Hospital

  collaborator OTHER

• Caoxian County Hospital

  collaborator UNKNOWN

• Qihe County People's Hospital

  collaborator UNKNOWN

• University Town Hospital, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

  collaborator UNKNOWN

• Dezhou Hospital Qilu Hospital of Shandong University

  collaborator OTHER

• The 2nd People's Hospital of Dongying City

  collaborator UNKNOWN

• Zhangdian District Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• Yantai Zhifu Hospital

  collaborator UNKNOWN

• Inner Mongolia Autonomous Region International Mongolian Medicine Hospital

  collaborator UNKNOWN

• Hohhot Second Hospital

  collaborator UNKNOWN

• Guanxian People's Hospital

  collaborator UNKNOWN

• Longkou People's Hospital

  collaborator UNKNOWN

• Linshu County Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• Yueyue Li

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-12-16

Primary Completion

2026-06-01

Completion

2026-08-01

Countries

• China

Study Locations