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Efficacies of Tetracycline-levofloxacin, Standard Bismuth, Amoxicillin-levofloxacin Quadruple Therapy for H.p

NCT05850117 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2023-05-09

No results posted yet for this study

Summary

1. Compare the efficacy of "Tetracycline combined with levofloxacin quadruple therapy", "standard tincture quadruple therapy" and "amoxicillin combined with levofloxacin quadruple therapy" on the second line of Helicobacter pylori sterilization.
2. To investigate the drug resistance of Helicobacter pylori and the host genotypes of CYP2C19 and IL-1B-511 on the sterilizing effect of three second-line Helicobacter pylori.

Conditions

  • Helicobacter Pylori Eradication

Interventions

DRUG

esomeprazole, tripotassium dicitrate bismuthate, tetracycline and levofloxacin

Tetracycline combined with levofloxacin quadruple therapy

DRUG

esomeprazole , tripotassium dicitrate bismuthate, tetracycline 500mg and metronidazole

standard tincture quadruple therapy

DRUG

esomeprazole, tripotassium dicitrate bismuthate , amoxicillin and levofloxacin

amoxicillin combined with levofloxacin quadruple therapy

Sponsors & Collaborators

  • Kaohsiung Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-10
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05850117 on ClinicalTrials.gov