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Menthol for Dyspnea Relief in Health and COPD

NCT05785026 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-11-19

No results posted yet for this study

Summary

Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown. The overall aim of this research project is to systematically examine the mechanisms of dyspnea relief from MI in healthy individuals and those with COPD.

Conditions

Interventions

OTHER

Menthol inhalation

300 milligrams of L-menthol will be deposited on to a cellulose swab and secured inside the lower portion of a sealed facemask.

OTHER

Strawberry scent

600 microliters of 100% natural strawberry flavoring will be deposited onto on to a cellulose swab and secured inside the lower portion of a sealed facemask.

OTHER

Menthol inhalation and facial airflow

Menthol will be administered using a noseplug and facial airflow will be applied with a tabletop fan.

OTHER

Strawberry scent and airflow to leg

Strawberry will be administered using a noseplug and airflow to the leg will be applied with a tabletop fan.

OTHER

Menthol inhalation and airflow to leg

Menthol will be administered using a noseplug and airflow to the leg will be applied with a tabletop fan.

OTHER

Strawberry inhalation and facial airflow

Strawberry will be administered using a noseplug and facial airflow will be applied with a tabletop fan.

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Daniel Langer · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2028-10-31
Completion
2028-10-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05785026 on ClinicalTrials.gov