Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus
NCT05779644 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 300
Last updated 2023-05-16
Summary
The purpose of this study is to analyze the effects of GLP-1RA on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.
Conditions
- Metformin
- Obesity, Abdominal
- Diabetes Mellitus, Type 2
- Abdominal Fat
- Non-Alcoholic Fatty Liver Disease
- Metabolism Disorder, Glucose
- Metabolism Disorder, Lipid
Interventions
- DRUG
-
Liraglutide is injected once a day.
- DRUG
-
Semaglutide is injected once a week.
- DRUG
-
Metformin is taken orally daily.
Sponsors & Collaborators
-
RenJi Hospital
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-02-23
- Primary Completion
- 2025-02-23
- Completion
- 2025-02-23
Countries
- China
Study Locations
More Related Trials
-
Effect and Safety of Benaglutide or Metformin in Patients With Simple Obesity Who Have Inadequate Weight Control
NCT03593668 ·Status: UNKNOWN ·Phase: PHASE4
-
Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity.
NCT04251156 ·Status: COMPLETED ·Phase: PHASE3
-
Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)
NCT07225816 ·Status: RECRUITING ·Phase: PHASE1
-
Pilot Study of the Effect of Liraglutide on Weight Loss and Gastric Functions in Obesity
NCT02647944 ·Status: COMPLETED ·Phase: PHASE2
-
STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity
NCT03811574 ·Status: COMPLETED ·Phase: PHASE3
-
The Effect and the Pharmacogenomics Study of Liraglutide in Obese Patients
NCT04839237 ·Status: WITHDRAWN ·Phase: PHASE2
-
Efficacy and Safety of Semaglutide Ingection in Subjects With Type 2 Diabetes
NCT05950516 ·Status: UNKNOWN ·Phase: PHASE3
-
Pilot Study of the Effect of Liraglutide 3.0 mg on Weight Loss and Gastric Functions in Obesity
NCT03523273 ·Status: COMPLETED ·Phase: PHASE2
-
Liraglutide-bolus vs Glargine-bolus Therapy in Overweight/Obese Type 2 Diabetes Patients (LiraGooD)
NCT03087032 ·Status: RECRUITING ·Phase: PHASE4
-
Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis
NCT01237119 ·Status: COMPLETED ·Phase: PHASE2
-
Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity
NCT07091500 ·Status: RECRUITING ·Phase: NA
-
Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity
NCT03552757 ·Status: COMPLETED ·Phase: PHASE3
-
The Effect of Liraglutide Versus Placebo When Added to Basal Insulin Analogues With or Without Metformin in Subjects With Type 2 Diabetes
NCT01617434 ·Status: COMPLETED ·Phase: PHASE3
-
The Efficacy and Safety of Liraglutide on Body Weight Loss in Obese and Overweight Patients
NCT04605861 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of Semaglutide Injection (HD1916) in Patients With Type 2 Diabetes Mellitus
NCT06161844 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of Liraglutide on Body Weight in Obese Subjects or Overweight Subjects With Co-morbidities
NCT04487743 ·Status: UNKNOWN ·Phase: PHASE3
-
The Effects of Glucose Control and Weight Loss Between Beinaglutide and Dulaglutide in Type 2 Diabetes With Overweight or Obesity.
NCT05005741 ·Status: UNKNOWN ·Phase: PHASE4
-
A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range
NCT06041217 ·Status: COMPLETED ·Phase: PHASE3
-
A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver
NCT05202353 ·Status: RECRUITING ·Phase: PHASE1
-
A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide
NCT00696657 ·Status: COMPLETED ·Phase: PHASE2
-
Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity
NCT03548987 ·Status: COMPLETED ·Phase: PHASE3
-
Semaglutide's Weight Loss Effects in Obesity
NCT06825793 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Influence of Liraglutide, a GLP-1 Receptor Agonist, on Brown Adipose Tissue (BAT) Activity in Humans
NCT02718950 ·Status: UNKNOWN ·Phase: PHASE3
-
Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes
NCT01399645 ·Status: COMPLETED ·Phase: PHASE2
-
PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults
NCT06863363 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4