Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis

Summary

The goal of this clinical trial is to clarify whether aggressive intravenous hydration with lactated Ringer's solution could reduce the incidence of post-ESWL pancreatitis in patients with chronic pancreatitis.

Conditions

• Pancreatitis, Chronic
• Pancreatic Duct Stone

Interventions

DRUG

Lactated ringers solution

Intravenous 20 mL/kg Ringer's lactate solution within 60 min from the start of ESWL, directly followed by 3 mL/kg per h for 8 h.

DRUG

normal saline

Intravenous fluid infusion with normal saline (maximum of 1.5mL/kg per h or 3L per 24h).

Sponsors & Collaborators

• Ruijin Hospital

  collaborator OTHER

• LanZhou University

  collaborator OTHER

• First People's Hospital of Hangzhou

  collaborator OTHER

• The Second Affiliated Hospital of Baotou Medical College

  collaborator OTHER

• Shanghai Pudong New Area Gongli Hospital

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• The Third Xiangya Hospital of Central South University

  collaborator OTHER

• Affiliated Hospital of Yunnan University

  collaborator OTHER

• Changhai Hospital

  lead OTHER

Principal Investigators

• Lianghao Hu, M.D. · Changhai Hospital

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-11-17

Primary Completion

2025-03-18

Completion

2025-03-23

Countries

• China

Study Locations