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Impact of Two Different Types of Sedation on ICEB

NCT05757063 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2023-12-18

No results posted yet for this study

Summary

The QT interval is a measure of the combination of cardiac depolarization and repolarization as it encompasses both the QRS complex and the J-T interval. QT, QTc, QTd prolongation or shortening has been associated with ventricular arrhythmias . In order to define non-torsogenic drug-induced arrhythmias, the index of cardio-electrophysiological balance (iCEB), which is a new marker calculated with the QT/QRS formula, has been defined. In our study, we planned to evaluate the effects of dexmedetomidine and propofol on cardiac electrophysiology with all these parameters, especially the newly defined iCEB.

Conditions

  • Propofol
  • Dexmedetomidine
  • Electrophysiological Balance Index
  • QT Interval, Variation in
  • Tp-e Interval
  • QT Dispersion
  • Knee Osteoarthritis

Interventions

OTHER

Sedation with propofol

After spinal anesthesia, patients will be sedated with propofol.

OTHER

sedation with dexmedetomidine

After spinal anesthesia, patients will be sedated with dexmedetomidine.

Sponsors & Collaborators

  • Ankara City Hospital Bilkent

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2023-07-01
Completion
2023-08-01

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05757063 on ClinicalTrials.gov